squalene synthase การใช้

• Squalene synthase homolog inhibition in Staphylococcus aureus is currently being investigated as a virulence factor-based antibacterial therapy.
• Development of squalene synthase knockout mice has demonstrated that loss of squalene synthase is lethal, and that the enzyme is essential for development of the central nervous system.
• Development of squalene synthase knockout mice has demonstrated that loss of squalene synthase is lethal, and that the enzyme is essential for development of the central nervous system.
• In cholesterol synthesis, the product, farnesyl pyrophosphate, is consumed in a reductive tail-to-tail condensation with another farnesyl pyrophosphate to form a 30-carbon compound called squalene by squalene synthase.
• Data suggests that accumulation of high levels of the metabolic substrate of squalene synthase and derivatives thereof account for the liver toxicity of squalene synthase inhibitors, and efforts to mitigate this substrate accumulation would likely be necessary for clinical success of a squalene synthase inhibitor
• Data suggests that accumulation of high levels of the metabolic substrate of squalene synthase and derivatives thereof account for the liver toxicity of squalene synthase inhibitors, and efforts to mitigate this substrate accumulation would likely be necessary for clinical success of a squalene synthase inhibitor
• Data suggests that accumulation of high levels of the metabolic substrate of squalene synthase and derivatives thereof account for the liver toxicity of squalene synthase inhibitors, and efforts to mitigate this substrate accumulation would likely be necessary for clinical success of a squalene synthase inhibitor
• It is used in the synthesis of CoQ ( part of the electron transport chain ), as well as being the immediate precursor of squalene ( via the enzyme squalene synthase ), dehydrodolichol diphosphate ( a precursor of dolichol, which transports proteins to the ER lumen for N-glycosylation ), and geranylgeranyl pyrophosphate ( GGPP ).
• Regulatory switches help control levels of ADS . Since enzyme substrate Farnesyl diphosphate has many uses in addition to forming amorpha-4, 11-diene, these other pathways regulate ADS . One such pathway is sterol biosynthesis, and in fact, the enzyme squalene synthase ( SS ) is considered a regulatory switch for ADS . When SS cDNA, which reduces SS mRNA concentration and therefore reduces expression of SS, is introduced into the plant cells, mRNA levels of ADS dramatically increased ( "'Figure 1 "').